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PHARMACOGENOMICS
IN ONCOLOGY
Emerging insights into the impact
of genetic
variability on cancer care
Brian Dingle, MD, MSc (Pharmacology),
FRCPC
Every gene in the human body is subject
to some degree of variation or polymorphism. A single nucleotide
polymorphism (SNP) is estimated to occur roughly every 1000
to 3000 base pairs,2 leading
to about 11 million SNPs per person. Most of these occur in
“non-coding regions” of DNA, i.e. that do not code
for a protein.
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