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Use
of corticosteroids in patients with brain metastasis
In search of evidence to guide
therapy
Rashmi Koul, MD; Arbind Dubey, MD;
Kalyani Vijay, MD; David D. Eisenstat, MD, FRCPC
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Metastasis to the brain, a potentially life-threatening complication
of systemic malignancy, is the most commonly reported intracranial
tumour in adults, and accounts for approximately 40% of intracranial
neoplasms. The incidence of brain metastasis is rising with the
increase in survival of cancer patients. Multiple, large autopsy
series suggest that, in order of decreasing frequency, cancers of
the lung, breast, skin (melanoma), kidney and colon are the most
common primary tumours to metastasize to the brain.1 In addition,
primary cancers of unknown origin sometimes present with brain metastases.
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