New developments: using miRNA genes to subtype renal cell carcinoma
and to classify neuroendocrine tumours of the lung
To view the complete article click
here (pdf format)
Commentary: Discovered by Lee et al in 1993, microRNA (miRNA) is a small noncoding RNA molecule that has a role in RNA silencing and posttranscriptional regulation of gene expression. The first association between miRNA and cancer was discovered in 2002, when miR-15 and miR-16 were identified at 13q14.3 region in chronic lymphocytic leukemia. Henceforth, the importance and significance of miRNA has been gradually recognized, and it has played an increasing role in cancer diagnosis.